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. 2018 Jan 17;8:2017. doi: 10.3389/fimmu.2017.02017

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Copyright © 2018 Takahashi, Katano, Ito, Goto, Abe, Mizuno, Kawai, Sugiyama and Ito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of lymph node (LN) organogenesis in γc-deficient mice using the pRORγt-γc transgene. A bacterial artificial chromosome (BAC)-transgenic (Tg) male founder mouse was crossed with female NOD/shi-scid-IL-2Rγ^null (NOG) mice. The presence of LNs in the F1 mice was macroscopically confirmed. Red circles indicate inguinal LNs (top panels) and para-aortic LNs in the abdomen (bottom panels).