Figure 2.

Bactericidal antibodies do not protect against typhoid infection but high bactericidal antibody activity reduces disease severity and cytokine response in vaccinated participants. (A–F) Correlation of disease parameters and plasma cytokine levels after diagnosis with SBA titers on D0 in participants from the Ty21a and M01ZH09 vaccine arms. Shown are day of diagnosis (A), bacterial load in blood on the day of diagnosis (B), symptom severity score (C), and maximum concentrations of cytokines TNFα, IL6, and IL8 [(D–F), respectively], in plasma samples collected within 48 h from diagnosis.