Table 4.

Association between variables and allopurinol-SCARs risk.

Predictor variables	Unadjusted OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value
Age (>58 vs. ≤ 58)	1.12 (0.485–2.609)	0.78	0.47 (0.08–2.54)	0.38
Gender (male vs. female)	0.588 (0.197–1.753)	0.34	1.295 (0.14–11.61)	0.82
HLA-B*5801 (+ vs. –)	63 (16.48–240.89)	< 0.001	38.01 (7.00–206.31)	< 0.001
PSORS1C1 methylation levels (≤ 0.9 vs. >0.9)	63.91 (13.25–308.16)	< 0.001	30.22 (4.73–192.96)	< 0.001

OR, odds ratio; CI, confidence interval; +, HLA-B^*5801 positive individuals; –, HLA-B^*5801 negative individuals. HLA-B^*5801 (+) allopurinol-SCARs patients have one copy of HLA-B^*5801.