Table 3.
Inhibition of C. difficile strains by lauric acid.
| C. difficile strain | Toxin genotype | MIC (mg/ml) | MBC (mg/ml) | Ribotype |
|---|---|---|---|---|
| R20291 | tcdA+tcdB+ (laboratory strains) | 0.08 | 0.31 | RT 027 |
| 630 | 0.08 | 0.31 | RT 012 | |
| TNHP 20 | tcdA+tcdB+ (clinical isolate strains) | 0.16 | 0.31 | RT 002 |
| TNHP 59 | 0.08 | 0.31 | RT 002 | |
| TNHP 207 | 0.16 | 0.31 | RT 106 | |
| TNHP 79 | tcdA-tcdB+ (clinical isolate strains) | 0.08 | 0.31 | RT 017 |
| TNHP 82 | 0.08 | 0.31 | RT 017 | |
| TNHP 403 | 0.16 | 0.31 | RT 017 | |
| TNHP 1 | tcdA-tcdB- (isolated from asymptomatic adults) | 0.08 | 0.31 | ND |
| TNHP 3 | 0.16 | 0.31 | ND | |
| TNHP 6 | 0.16 | 0.31 | ND |
Clostridium difficile isolates containing two laboratory strains and nine local isolates were exposed to various concentration of lauric acid for 24 h. MBC was determined as described previously. Results are expressed as average of at least three independent replicates. ND – not determined.