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. 2018 Jan 17;9:1. doi: 10.3389/fphar.2018.00001

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Copyright © 2018 Dinić, Pecikoza, Djokić, Stepanović-Petrović, Milenković, Stevanović, Filipović, Begović, Golić and Lukić.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of EPS CG11 (EPS) on carrageenan (CAR)-induced paw edema (A) and mechanical hyperalgesia (B). The results are expressed as: (A) the difference, in milliliters, between the post-treatment and basal paw volumes (dV) and (B) the difference, in grams, between basal and the post-treatment paw withdrawal thresholds (df). EPS was administered i.p. 60 min before the CAR injection (denoted by arrows). Each point represents the mean ± SEM of dV (ml) or df (g). Statistical significance (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001; two-way repeated measures ANOVA followed by Tukey HSD test) was determined by comparison with the curve of the control group. i.p., intraperitoneal; i.pl., intraplantar.