Table 1.
The PK parameters of FF after I.M and I.V administrations (30 mg/kg) in pigs (n = 8).
| Parameters | Unites | I.M | I.V |
|---|---|---|---|
| Ke | h-1 | 0.048 ± 0.004 | 0.106 ± 0.015 |
| t1/2ke | H | 14.46 ± 1.84 | 6.54 ± 0.75 |
| Clb | L/h⋅kg | 0.185 ± 0.027 | 0.187 ± 0.032 |
| AUC | μg⋅h/ml | 158.56 ± 13.46 | 159.93 ± 13.28 |
| AUC0-24h | μg⋅h/ml | 88.85 ± 6.72 | 154.18 ± 11.12 |
| Cmax | μg/ml | 4.44 ± 1.02 | – |
| Tmax | H | 4 ± 1.34 | |
| MRT | H | 26.11 ± 3.24 | 5.85 ± 1.17 |
| F | – | 99.14% | – |
Ke, presented elimination rate constant; t1/2ke, presented elimination half-life; Clb, presented body clearance; AUC, presented area under the curve; AUC0-24h, presented area under the curve from 0 to 24 h; Cmax, peak concentration; Tmax, the time of maximum serum concentration; the MRT, presented mean residence time; F, the bioavailability.