Table 3.
The main parameters of PK/PD modeling for FF against SS ex vivo after I.M administration in pigs (n = 8).
| Parameters | Unites | Mean ± SD |
|---|---|---|
| Emax | Lg CFU/ml | 2.36 ± 0.48 |
| EC50 | h | 42.22 ± 1.20 |
| N | – | 9.89 ± 1.15 |
| AUC0-24h/MIC for bacteriostatic (E = 0) | h | 37.89 ± 4.25 |
| AUC0-24h/MIC for bactericidal (E = -3) | h | 44.02 ± 4.85 |
| AUC0-24h/MIC for eradication (E = -4) | h | 46.42 ± 6.45 |
Emax, presented the Lg change in bacterial counts of blank sample; EC50, presented the value to achieve 50% maximal antibacterial effect; N, presented the Hill coefficient, Hill, the dose-response curve slop.