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. 2018 Jan 17;9:5. doi: 10.3389/fphar.2018.00005

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Copyright © 2018 Qin, Wang, Li, Deokar, Buolamwini and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SP141 inhibits the expression of β-catenin and its target genes in pancreatic tumors in vivo. SP141 was administered by intraperitoneal injection (40 mg/kg/day, 5 days/week) to nude mice bearing Panc-1 and AsPC-1 orthotopic tumors for 5 and 4 weeks, respectively. The tumor tissues were analyzed for (A) the protein expression of β-catenin, c-Myc, and cyclin D1 by immunohistochemistry (scale bar: 20 μm) and (B) the protein expression of β-catenin, phosphorylated β-catenin at Ser45 and at Ser33/37/Thr41, c-Myc, and cyclin D1 by Western blotting (each lane represents a different tumor sample).