Table I.
Secondary tumours of the ampulla of Vater-literature overview and case report.
| Authors, year | No. | Sex | Age at diagnosis of metastasis | Macroscopy of ampullary lesion | Location of primary tumour | Diagnosis of primary tumour | Time interval between diagnosis of primary tumour and metastasis | Symptomsa | Additional metastases (at time of diagnosis of ampullary tumour) | Therapyb | Outcome | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| England and Sarr, 1990 | 1 | M | 70 | NS | Skin: posterior thorax | Malignant melanoma | 3 years | 1, 3, 4 | Bone, liver | 3, 4, 5 | NS | (6) |
| Sans et al, 1996 | 2 | M | 51 | 1 | Skin (NS) | Malignant melanoma | 3 months | 1, 3 | Brain | 2 | Succumbed after 3 months | (7) |
| Meyers et al, 1998 | 3 | M | 56 | 1, 3 | Skin: left upper back | Malignant melanoma | 3 years | 2, 3 | Brain, skin | 3 | Succumbed after 4,5 months | (8) |
| Caballero-Mendoza et al, 1999 | 4 | M | 48 | NS | Skin: back | Malignant melanoma | Synchronous | 1, 3, 4 | Lungs, stomach, mediastinum, liver, spleen | 2, 4 | Succumbed after 4 months | (9) |
| Le Borgne et al, 2000 | 5 | F | 62 | 3 | Skin (NS) | Malignant melanoma | 8 years | 3 | No | 3, 4 | No evidence of disease 12 months after resection | (10) |
| Le Borgne et al, 2000 | 6 | F | 33 | 3 | Skin (NS) | Malignant melanoma | NS | 3 | NS | 3 | Survived 2 months after resection | (10) |
| van Bokhoven et al, 2006 | 7 | F | 66 | 1 | Skin: left side of the trunk | Malignant melanoma (2 primary lesions) | 3 years | 1, 3 | No | 2 | NS | (11) |
| Marks et al, 2010 | 8 | F | 66 | 1, 3 | Skin: right forearm | Malignant melanoma | 4 years | 1, 3 | Right superior eyelid, chest, gallbladder, abdomen, pelvis, superficial soft tissue | 2, 4 | Succumbed after 15 months | (12) |
| Uiterwaal et al, 2011 | 9 | F | 41 | NS | Skin: left shoulder | Malignant melanoma | 10 months | 1 | Brain | 4, 5 | Succumbed 8 months | (13) |
| Nakayama et al, 2011 | 10 | F | 81 | 1 | Vagina | Malignant melanoma | Synchronous | 2, 4 | Liver, the primary lesion extended to the cervix of uterus and to the pelvis, behind the bladder | 1 | Succumbed after 1 month | (14) |
| McKenna and Kozarek, 1989 | 11 | M | 52 | 1 | Kidney (right) | Clear cell carcinoma | 10 years | 3, 4 | Left kidney, right lower pulmonary lobe | 2, 3 | NS | (15) |
| Robertson and Gertler, 1990 | 12 | M | 70 | 1, 2, 3 | Kidney (left) | Clear cell carcinoma | 12 years | 2, 4 | No | 3 | NS | (16) |
| Venu et al, 1991 | 13 | M | 64 | 1, 2 | Kidney (left) | Clear cell carcinoma | 11 years | 2, 4 | Bone | 3, 4 | Succumbed postoperatively due to massive pulmonary embolism | (17) |
| Bolkier et al, 1991 | 14 | F | 55 | 1 | Kidney (left) | Clear cell carcinoma | NS | 3 | Left breast, brain | 2 | Succumbed after 2 months | (18) |
| Leslie et al, 1996 | 15 | F | 78 | 1, 3 | Kidney (left) | Clear cell carcinoma | 10 years | 3, 4 | No | 3 | No evidence of disease 2.5 years after resection | (19) |
| Leslie et al, 1996 | 16 | M | 53 | 1, 3 | Kidney (right) | Clear cell carcinoma | 8 years | 2, 4 | Mesenteric nodulation, retroperitoneal mass | 3, 4 | Alive with residual disease 6.5 years after resection | (19) |
| Janzen et al, 1998 | 17 | M | 75 | 1, 3 | Kidney (left) | Clear cell carcinoma | 17.5 years | 2, 3 | Spleen | 3 | NS | (20) |
| Mendoza et al, 2001 | 18 | M | 49 | 1, 2, 3 | Kidney (right) | Clear cell carcinoma | 2.5 years | 1, 2 | No | 3 | Succumbed after 3 months | (21) |
| Hata et al, 2013 | 19 | F | 50 | 1, 2, 3 | Kidney (left) | Clear cell carcinoma | 13 years | 2 | Bone, spleen | 3 | Alive with residual disease 1 year after resection | (22) |
| – | 20 | M | 57 | 1, 2, 3 | Kidney (left) | Clear cell carcinoma | 3.5 years | 2 | No | 3 | No evidence of disease 4 years after resection | Present case |
| Haidong et al, 2014 | 21 | M | 50 | NS | Kidney (right) | Clear cell carcinoma | Synchronous | 3 | No | 3,4 | No evidence of disease 5 years after resection | (32) |
| Titus et al, 1997 | 22 | F | 50 | 1, 3 | Breast (left) | Invasive carcinoma of no special type | 4 years | 3 | No | 3, 4 | alive after 4 months | (23) |
| Rego et al, 2009 | 23 | F | 66 | NS | Breast (left) | Invasive carcinoma of no special type | 2 years | 4 | No | 4 | NS | (24) |
| Rego et al, 2009 | 24 | F | 39 | 1 | Breast (NS) | Invasive lobular carcinoma | NS | 1 | NS | 3 | NS | (24) |
| Bastos et al, 2014 | 25 | F | 63 | 1 | Breast | Invasive lobular carcinoma | 1.5 years | 1,3 | Lumbar spine | 2 | NS | (33) |
| Lee et al, 2005 | 26 | F | 50 | 1, 2 | Uterine cervix | Squamous cell carcinoma | 2 years | 1 | No | 4 | NS | (25) |
| Sreenarasimhaiah and Hoang, 2005 | 27 | M | 62 | 1 | Oesophagus | Squamous cell carcinoma | Synchronous | NS | No | 4, 5 | NS | (26) |
| Buyukcelik et al, 2003 | 28 | M | 71 | 1, 2, 3 | Larynx | Squamous cell carcinoma | 5 years | 1, 3 | Right adrenal gland, multiple pulmonary nodules | 2, 4 | Succumbed after 1 year | (27) |
| Kamusella et al, 2007 | 29 | M | 41 | 1, 2 | Lung (right superior lobe) | Adenocarcinoma | Synchronous | NS | No | 2 | NS | (28) |
| Silva et al, 1996 | 30 | F | 53 | NS | Ovary and uterus | Endometrioid adenocarcinoma (both ovaries and endometrium) | 5 years | 1, 2, 3 | NS | 2, 4 | No evidence of disease 9 months after resection | (29) |
| Green et al, 2008 | 31 | M | 54 | 1 | Bladder | Urothelial carcinoma | 3 years | 1, 3 | No | 2, 4 | NS | (30) |
| Kadakia et al, 1992 | 32 | M | 27 | 1, 2 | Right femur | Osteosarcoma | 4 years | 1, 2, 4 | NS | NS | NS | (31) |
a
1, upper GI complaint (including nausea, vomiting and pain); 2, bleeding (including melena and anaemia); 3, jaundice and related symptoms (including pruritus, alterations in stool and urine); 4, general discomfort, weakness, weight loss and/or shortness of breath.
b
1, best supportive care; 2, drainage and/or stent; 3, surgery; 4, chemotherapy; 5, radiotherapy. F, female; M, male; DOD, dead of disease; NS, not specified. 1, polyp/mass; 2, ulcer; 3, pancreatic involvement