Table 1.

The effect of metformin (1 and 10 mg/kg for 6 weeks) on anxiety-like behaviors and locomotor activity of D-galactose-induced aging mice

	Groups
	Control	Met 1	D-gal	Met 1+D-gal	Met 10+D-gal
Open arm time (%)	28.33±2.87	57.39±2.11###	15.02±3.53#	55.28±3.49***	52.33±3.43***
Open arm entries (%)	30.65±2.47	54.19±1.82###	17.83±3.81#	47.37±3.31***	49.53±2.09***
Total arm entries (n)	25.29±1.86	25.57±1.13	21.00±2.42	23.00±0.53	23.57±1.39

Values are expressed as mean±SEM (n=10 in each group);

^#P<0.05 and

^###P<0.001 compared to the control group;

^***P<0.001 compared to the D-gal group