Table 4.
Hepato-nephro-toxic impacts of grape seed extract and indomethacin in rats at groups (I-IV)
| Parameters Treatments |
ALT (U/l) | AST (U/l) | ALP (IU/l) | T. proteins (g/dl) | Albumin (g/dl) | Urea (mg/dl) | Creatinine (mg/dl) |
|---|---|---|---|---|---|---|---|
| Cn | 27.65c±1.33 | 16.00c±1.73 | 23.00c±1.73 | 6.30a±0.26 | 3.63a±0.09 | 30.00c±2.51 | 0.93c±0.52 |
| GSE | 27.00c±3.51 | 15.00c±1.15 | 23.67c±1.33 | 6.23a±0.14 | 3.53a±0.24 | 28.80c±2.23 | 0.87c±0.37 |
| Indo | 73.44a±5.45 | 48.00a±2.31 | 60.00a±3.05 | 5.23b±0.35 | 2.40bc±0.17 | 58.77a±2.08 | 4.70a±0.91 |
| GSE+Indo | 31.00b±0.96 | 20.00b±1.00 | 28.00b±1.16 | 5.77ab±0.24 | 2.80b±0.23 | 39.47b±5.09 | 2.00b±0.32 |
Each value represents the mean of 5 rats±E
All data having different letters are differ significantly at the same column at P≤0.05
Cn: Control; Cg: Carrageenan; GSE: Grape seeds extract; Indo: Indomethacin.; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase;T. proteins: Total proteins