Table IV.
Chemical and histological findings at 8 weeks after diabetic nephropathy induction.
| Parameter | Control | TAG | Low-DAG | High-DAG |
|---|---|---|---|---|
| SCr (umol/l) | 73.6±4.14 | 194.5±13.53a | 191.9±9.23a | 186.6±6.87a |
| BUN (mmol/l) | 8.79±1.79 | 15.14±1.86a | 14.83±1.11a | 14.48±0.71a |
| HbA1c (%) | 5.13±0.79 | 13.57±1.50a | 12.77±1.36a | 11.93±1.47a |
| Insulin (mmol/l) | 1.11±0.07 | 1.68±0.11a | 1.60±0.12a | 1.53±0.15a,b |
| KI (g/kg) | 5.18±0.60 | 10.89±1.14a | 9.93±2.43a | 7.44±1.63a,b |
| AGEs (ng/mg) | 22.31±1.85 | 46.96±3.02a | 44.32±3.60a | 33.21±3.58a,b |
a
P<0.05 vs. control group
b
P<0.05 vs. TAG group. Quantitative data are expressed as the mean ± standard deviation (n=10), and were analyzed by one-way analysis of variance. Multiple comparisons between the groups were performed using the least significant difference t-test method. TAG, triacylglycerol; DAG, diacylglycerol; SCr, serum creatinine; BUN, blood urea nitrogen; HbA1c, glycohemoglobin A1c; KI, kidney index; AGEs, advanced glycation end products.