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. 2017 Dec 1;15(2):1269–1276. doi: 10.3892/etm.2017.5588

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Paclitaxel treatment regulates growth and aggressiveness of breast cancer cells through Aurora kinase-mediated cofilin-1 activity. (A) Knockdown of Aurora kinase (Si-AKN) suppresses Aaurora kinase expression in MCF-7 and SKBR3 cells. (B) Overexpression of Aurora kinase (pAKN) promotes Aaurora kinase expression in MCF-7 and SKBR3 cells. (C) Knockdown of Aurora kinase (Si-AKN) decreases cofilin-1 expression in MCF-7 and SKBR3 cells. (D) Overexpression of Aurora kinase (pAKN) promotes cofilin-1 expression in MCF-7 and SKBR3 cells. (E) Si-AKN enhances the inhibitory effects of Paclitaxel on growth of MCF-7 and SKBR3 cells. (F) pAKN cancels Paclitaxel-inhibited growth of MCF-7 and SKBR3 cells. (G and H) Si-AKN significantly inhibits migration (G) and invasion (H) of MCF-7 and SKBR3 cells. (I and J) pAKN transfection cancels Paclitaxel-inhibited migration (I) and invasion (J) of MCF-7 and SKBR3 cells. All data were expressed as mean ± SD of three independent experiments using Student's t-test or one-way ANOVA or Kruskal-Wallis test. *P<0.05, **P<0.01 vs. control group. NS, no significant difference.

Figure 4. — Paclitaxel treatment regulates growth and aggressiveness of breast cancer cells through Aurora kinase-mediated cofilin-1 activity. (A) Knockdown of Aurora kinase (Si-AKN) suppresses Aaurora kinase expression in MCF-7 and SKBR3 cells. (B) Overexpression of Aurora kinase (pAKN) promotes Aaurora kinase expression in MCF-7 and SKBR3 cells. (C) Knockdown of Aurora kinase (Si-AKN) decreases cofilin-1 expression in MCF-7 and SKBR3 cells. (D) Overexpression of Aurora kinase (pAKN) promotes cofilin-1 expression in MCF-7 and SKBR3 cells. (E) Si-AKN enhances the inhibitory effects of Paclitaxel on growth of MCF-7 and SKBR3 cells. (F) pAKN cancels Paclitaxel-inhibited growth of MCF-7 and SKBR3 cells. (G and H) Si-AKN significantly inhibits migration (G) and invasion (H) of MCF-7 and SKBR3 cells. (I and J) pAKN transfection cancels Paclitaxel-inhibited migration (I) and invasion (J) of MCF-7 and SKBR3 cells. All data were expressed as mean ± SD of three independent experiments using Student's t-test or one-way ANOVA or Kruskal-Wallis test. *P<0.05, **P<0.01 vs. control group. NS, no significant difference.