Table 3.

Testicular histopathology in rat offspring exposed perinatally to mixtures of endocrine disrupters (selected data).

	PD 16			PD 22			PD 300
Dose groups	N	Percentage of tubules with lumen, mean ± s.d.	Tubular diameter, mean ± s.d.	N	Percentage of tubules with lumen, mean ± s.d.	Tubular diameter, mean ± s.d.	N	Normal epithelium	Seminiferous epithelium atrophy, Sertoli cell only	Seminiferous epithelium atrophy, spermatogenesis until pachytene stage	Focal atrophy 5–25% of tubules	Edema	Dilatation
Control	14	33.2 ± 27.8	82.1 ± 3.5	12	81.6 ± 8.9	111.7 ± 4.8	18	17	0	1	0	1	0
TotalMix450	10	10.5 ± 11.6*	79.7 ± 4.1	10	81.9 ± 3.7	110.9 ± 6.1	16	15	1	0	0	1	1
AAMix450	11	30.5 ± 15.3	83.2 ± 3.3	10	77.5 ± 9.9	111.4 ± 4.6	16	16	0	0	0	1	1
EMix450	10	30.8 ± 37.7	80.7 ± 4.6	9	78.0 ± 7.6	112.0 ± 3.5	16	14	1	0	1	1	1
PM	11	18.8 ± 14.3	83.5 ± 5.3	9	87.2 ± 4.5	115.6 ± 4.4	14	13	0	0	1	2	0

*Indicates value statistically significantly different from controls (P < 0.05, non-parametric Dunn’s test).