Table 2.

Presenting symptoms of adult patients with pheochromocytomas, also divided into how they presented.

	All (n = 92)	Incidentaloma presentation (n = 59)	Pheo suspicion (n = 29)	P value incidentaloma vs Pheo suspicion	Screening (n = 4)	P value between all three groups
Paroxysmal symptoms (n)	57 (62%)	29 (49%)	26 (90%)	<0.001	2 (50%)	0.001
Headaches (n)	34 (37%)	17 (29%)	16 (55%)	0.020	1 (25%)	0.048
Palpitation (n)	49 (53%)	26 (44%)	22 (76%)	0.006	1 (25%)	0.010
Sweating (n)	38 (41%)	23 (39%)	15 (52%)	0.360	0 (0%)	0.120
Pallor (n)	11 (12%)	3 (5%)	7 (24%)	0.013	1 (25%)	0.025
Anxiety (n)	42 (46%)	26 (44%)	13 (45%)	0.872	3 (75%)	0.483
Feeling hot/flush (n)	22 (24%)	13 (22%)	9 (31%)	0.434	0 (0%)	0.336
Nausea (n)	20 (22%)	8 (14%)	12 (41%)	0.006	0 (0%)	0.007
Weight loss (n)	15 (16%)	11 (19%)	4 (14%)	0.765	0 (0%)	0.563
Tiredness (n)	26 (28%)	18 (31%)	8 (28%)	0.973	0 (0%)	0.421
Tremor (n)	13 (14%)	4 (7%)	8 (28%)	0.017	1 (25%)	0.025
Orthostatic symptoms (n)	25 (27%)	11 (19%)	13 (45%)	0.019	1 (25%)	0.034
No symptoms at all (n)	8 (9%)	7 (12%)	0 (0%)	0.090	1 (25%)	0.089
Different symptoms (n)	3 (0–10)	3 (0–10)	4 (2–8)	<0.001	1 (0–6)	0.001
Classic triad (n)	16 (17%)	8 (14%)	8 (28%)	0.143	0 (0%)	0.170

Pheo, pheochromocytoma. All patients screened due to familial syndrome had a previously known RET mutation (MEN2A). Bold, P < 0.05. The classic triad with paroxysmal symptoms was defined as headaches, sweating and palpitation.