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Electrophysiological and pharmacological profiles of heteromeric ASICs
| Protein | pH50 activation | Non-proton ligand | Inhibitor | Distribution |
|---|---|---|---|---|
| ASIC1a/2a | 5.5–5.8 | MitTx | Mambalgins | PNS, CNS |
| ASIC1a/2b | 6.2 | ND | PcTx1; Mambalgins | PNS, CNS |
| ASIC1a/3 | 6.3 | MitTx | APETx2 | PNS |
| ASIC1b/3 | 6.0–6.2 | ND | APETx2 | PNS |
| ASIC2a/3 | 5.7 | MitTx | Amiloride | PNS |
| ASIC2b/3 | 6.5 | ND | APETx2 | PNS |
| ASIC1a/1b | 6.0 | ND | Mambalgins | PNS |
ND not determined, PNS peripheral nervous system, CNS central nervous system
