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A) In a subset of 45 subjects who also participated in a hyperinsulinemic-euglycemic clamp, there was an interaction effect between diagnosis and genotype. Steady-state FFA levels were higher during hyperinsulinemia in AD APOE4 non-carriers compared to ND APOE4 non-carriers, indicating of insulin resistance. D) There was a strong inverse correlation between steady state glucose disposal rate and FFA levels. Bars are shown as means ± SE. *p<0.05 for diagnosis x genotype interaction.
