Table 2. Hazard Ratios for Motor Function Scores and Putative SMA Biomarkers.

Estimated hazard ratios from proportional hazards regression – time to combined endpoint

Predictor	Estimated hazard ratio (95% CI) SMA cohort excluding SMN2 > 2 (n = 20)	Estimated hazard ratio (95% CI) Total SMA cohort (n = 26)
Weight**	1.71 (0.93, 3.14)	1.65 (0.91, 3.01)
TIMPSI*	0.80 (0.35, 1.82)	0.53 (0.30, 0.93)
CHOP-INTEND*	0.94 (0.41, 2.20)	0.69 (0.38, 1.27)
CMAP peak amplitude**	0.56 (0.04, 7.43)	0.31 (0.06, 1.60)
CMAP peak area**	0.82 (0.28, 2.43)	0.55 (0.26, 1.16)

^*Hazard ratio shown for a 10 unit increase

^**Hazard ratio shown for a 1 unit increase

For SMN2 copy number, the risk of endpoint for subjects with SMN2 copy number equal to two is 8.13 times that of subjects where copy number is greater than two, 95% CI (1.05, 63.00)