. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: Aliment Pharmacol Ther. 2017 Dec 15;47(4):494–503. doi: 10.1111/apt.14471

Table 4.

Combination of anti-H. pylori titer and CagA seropositivity with pepsinogen I on risk of noncardia gastric cancer in ATBC Study

	control (n=3,291)		case (n=197)		model 1		model 2
	N	%	N	%	OR	95% CI	OR	95% CI
Anti-H. pylori antibody titer in all noncardia cancer (n=197)
Group A	736	22.4	14	7.1	ref		ref
Group B + low titer H. pylori^b	1,571	47.7	92	46.7	3.21	1.82–5.68	3.34	1.85–6.03
Group B + high titer H. pylori	686	20.8	51	25.9	4.15	2.27–7.58	4.17	2.23–7.79
Group C + low titer H. pylori^b	186	5.7	25	12.7	7.96	4.03–15.73	8.09	4.00–16.37
Group C + high titer H. pylori	93	2.8	10	5.1	6.34	2.72–14.78	6.31	2.59–15.35
Group D	19	0.6	5	1.9	15.66	5.08–48.25	16.57	5.27–52.13
p-trend					<0.0001		<0.0001
Anti-CagA seropositivity in all noncardia cancer (n=186)^a
Group A	736	24.1	14	7.5	ref		ref
Group B + CagA (−)^c	590	19.4	25	13.4	2.37	1.22–4.60	2.45	1.23–4.88
Group B + CagA (+)	1,451	47.6	110	59.1	4.18	2.38–7.36	4.34	2.41–7.79
Group C + CagA (−)^c	46	1.5	11	5.9	14.14	6.04–33.11	13.33	5.47–32.47
Group C + CagA (+)	207	6.8	21	11.3	6.03	2.99–12.15	6.28	3.04–12.98
Group D	19	0.6	5	2.7	15.71	5.09–48.42	16.73	5.31–52.68
p-trend					<0.0001		<0.0001

Abbreviations: ATBC - Alpha-Tocopherol, Beta-Carotene Cancer Prevention, OR – odds ratio, CI – confidence interval, SPGI- Serum pepsinogen I,

Group A: H. pylori (−) and normal SPGI, Group B: H. pylori (+) and normal SPGI, Group C: H. pylori (+) and low SPGI, Group D: H. pylori (−) and low SPGI

model 1: adjusted for age at randomization and type of intervention

model 2: model 1 + body mass index, pack years of smoking, alcohol drinking, education, fruit intake, and vegetable intake

excluded with missing CagA status (11 cases & 242 controls) or H. pylori negative/CagA positive cases (157 controls)

Within group B high titer vs. low titer H. pylori (P_{heterogeneity} = 0.23), group C high titer vs. low titer H. pylori (P_{heterogeneity} =0.52) in model 2

Within group B CagA (+) vs. CagA (−) (P_{heterogeneity} = 0.01), group C CagA (+) vs. CagA (−) (P_{heterogeneity} =0.06) in model 2