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. Author manuscript; available in PMC: 2018 Jan 22.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Apr 17;25(21):4950–4955. doi: 10.1016/j.bmcl.2015.04.036

Table 2.

CYP450 and hERG parameters for 49b, 51b, 2, and 7

Compound CYP450 (% @ 1 μM)a hERGb (%)
2C19 2D6 3A4 1 μM 10 μM
49b 2 19 0 18 55
51b 2 41 0 37 79
2 20 100 35 — —
7 0 8 6 50 93
a

Isolated human enzymes and fluorometric substrates.

b

Displacement of 3H-dofetilide in HEK293 cells.