. Author manuscript; available in PMC: 2018 Aug 31.

Published in final edited form as: Semin Immunol. 2017 Aug 31;30:36–44. doi: 10.1016/j.smim.2017.08.008

Table 1.

Examples of OIT strategies.

Form of OIT	Type of drug	Mechanism
Prevention	Oral allergen administration	Effects may include increased function of Ag-specific CD4⁺FOXP3⁺ T_reg
Treatment	Oral allergen administration	Effects may include increased function of Ag-specific CD4⁺FOXP3⁺ T_reg
With adjunct omalizumab	Humanized mouse mAb to IgE	Binds free and membrane-bound IgE, but not IgE bound to FcεRI or CD23
With adjunct mepolizumab	Humanized mouse mAb to IL-5	Blocks IL-5-mediated signaling (Fig. 2)
With adjunct rezlisumab	Humanized mouse mAb to IL-5	Blocks IL-5-mediated signaling (Fig. 2)
With adjunct ANB020	Humanized mAb to IL-33	Blocks IL-33-mediated signaling (Fig. 2)