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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Hematol Oncol Clin North Am. 2017 Apr;31(2):317–334. doi: 10.1016/j.hoc.2016.11.006

Table 6.

Histological morphologies of LyP

Type % of cases Histologically Mimicks Description
A 47–82% Hodgkin lymphoma
Transformed MF
• Large Reed-Sternberg-like atypical lymphocytes
• Wedge-shaped heterogeneous infiltrate with lymphocytes, neutrophils, eosinophils and histiocytes
B 4–17% MF • Epidermotropic band-like infiltrate
• Small irregular lymphocytes
• Cerebriform nuclei
C 7–22% ALCL • Sheets or clustered infiltrate
• Large atypical lymphocytes
• Few inflammatory cells
D ~8% Primary cutaneous aggressive CD8+ cytotoxic T-cell lymphoma (TCL), PLC/PLEVA
Pagetoid reticulosis
Cutaneous gamma/delta TCL
• Epidermotrophic infiltrate
• CD8+
• Small to medium atypical lymphocytes
E ~0.6% Angiocentric:
Extranodal NK/T-cell lymphoma, nasal type
Cutaneous gamma/delta TCL
ALCL variant with angiocentric and/or angiodestructive growth
• Small- to medium-sized lymphocytes
• Angiocentric: CD8+ infiltrating walls of small to medium-sized vessels
• Vasculitis: fibrin, thromboses and extravasation of red blood cells
F58 5–10% Folliculotropic:
Folliculotropic MF
Pseudolymphoma
Connective tissue diseases
• Perifollicular infiltrate
• Medium to large lymphoid cells
• Follicular mucinosis
• Neutrophils within infundibula
Mixed 4–9% • More than 1 histological type in the same patient or lesion

Data from references 20, 24, 30, 58, 69

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