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Immunohistochemical profile of LyP and ALCL
| LyP | pcALCL | scALCL | |
|---|---|---|---|
| Clonality | 40–100% | >90% | ~90% |
| CD30 | + (type B, variably) | >75% + (required for diagnosis) | + |
| CD56 | ~10% | 12–75% | + (worst prognosis) |
| Bcl-2 | − | 30% | + |
| Cytotoxic molecules: TIA-1, Granzyme B or Perforin | + | ~50% | + |
| ALK | − | Rare | 50% |
| CLA | + | Variable | − |
| EMA | − | − | + |
| t(2;5)(pq23;q35) translocation | − | <10% | 70–75% |
Data from references 30, 59, and 60
