Table 8.
CD30+ Work-up
| LyP | pcALCL | scALCL | |
|---|---|---|---|
| History | |||
| Spontaneous regression | ✓ | ✓ | x |
| Previous Lymphoid Neoplasms (MF, nodal ALCL or Hodgkin lymphoma) | ✓ | x | ✓ |
| Immunosuppression | x | x | x |
| B symptoms | x | x | ✓ |
| Physical exam | |||
| Solitary lesion | x | ✓ | ✓ |
| Many lesions | ✓ | x | ✓ |
| Patches/plaques of MF | ✓ | x | x |
| Enlarged Lymph Nodes | x | x | ✓ |
| Hepatosplenomegaly | x | x | ✓ |
| Laboratory investigations | |||
| Abnormal CBC with differential | x | x | ✓ |
| Abnormal LDH | x | x | ✓ |
| Serology for HTLV-1/2 | x | x | x |
| Other investigations | |||
| Contrast enhanced CT ± PET of chest, abdomen and pelvis or whole body integrated PET-CT | x | ✓ | ✓ |
| Bone marrow aspirate or biopsy | x | Only if radiologic evidence of extracutaneous disease | ✓ |
| Lymph node biopsy if > 1.5cm | x | If >1.5cm palpable or evidence on imaging | ✓ |
Adapted from: Kempf W, Pfaltz K, Vermeer MH, et al. EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. Blood 2011; 118:4024, with permission.