Extended Data Figure 7. Replication of cis-eQTLs between tissues.

a, π₁ statistics for cis-eQTLs are reported for all pairwise combinations of discovery (y-axis) and replication (x-axis) tissues. Higher π₁ values indicate a stronger replication signal. Tissues are grouped using hierarchical clustering on rows and columns separately with a distance metric of 1 − ρ, where ρ is the Spearman’s correlation coefficient of π₁ values. π₁ is calculated only when the gene is expressed and testable in the replication tissue. b, c, π₁ replication is reported between tissues subsampled down to 70 non-matched (b) and matched (c) donors. In (c), grey tiles indicate tissue pairs with fewer than 70 shared donors. d, Effect of sample size (x-axis) on average π₁ replication (y-axis) across all replication tissues. e, Scatter plot of π₁ scores among tissue pairs with matched (x-axis) and non-matched (y-axis) donors.