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. Author manuscript; available in PMC: 2018 Jan 22.
Published in final edited form as: Nature. 2017 Oct 11;550(7675):204–213. doi: 10.1038/nature24277

Extended Data Figure 16. Broad trans-regulatory locus 9q22 in thyroid tissue.

Extended Data Figure 16

a, FOXE1 expression is thyroid-specific. b, Correlation between FOXE1 expression levels and thyroid PEER factors, compared to 100 random genes. For every gene, absolute correlation was sorted in decreasing order. The correlation of FOXE1 with the fifth, sixth, seventh and eighth PEER factors was significantly higher than the correlation of random genes at those rank ordered PEER factors (empirical P ≤ 0.05). c–e, Variants in the chr 9q22 locus were enriched for association with genes on other chromosomes in thyroid carcinomas compared to randomly selected variants nearby randomly selected genes. We used variants that were found within 35 kb upstream or downstream of the gene TSS. f, rs10759975 is associated with trans-eGene TMEM253. g, rs10759975 is associated with trans-eGene ARFGEF3. h, rs10759975 shows cis association with TRMO. i, rs10759975 is weakly associated in cis with FOXE1. Box plots depict the IQR, whiskers depict 1.5× IQR.