Table 2.
Multiple logistic regression analyses on the association of hsCRP and Alzheimer disease (AD)
| AD | NCa | Debut AD 0.4-7 years later | NCa | Debut AD 7-15 years later | NCa | |||
|---|---|---|---|---|---|---|---|---|
| (1) Age ≥60b | n = 2150 | 52 | (4) Age ≥ 60 | n = 2150 | 23 | (7) Age ≥ 60 | n = 2150 | 29 |
| Model 1c | .77 (.47-1.26) | Model 1 | .80 (.39-1.67) | Model 1 | .84 (.41-1.71) | |||
| Model 2d | .75 (.46-1.24) | Model 2 | .82 (.39-1.73) | Model 2 | .80 (.39-1.64) | |||
| Model 3e | .78 (.47-1.32) | Model 3 | .86 (.39-1.86) | Model 3 | .83 (.39-1.75) | |||
| Model 4f | .82 (.49-1.38) | Model 4 | .93 (.42-2.04) | Model 4 | .83 (.39-1.77) | |||
| hsCRP*Age | .93 (.87-.99) | hsCRP*Age | .88 (.80-.97) | hsCRP*Age | .59 (.70-4.70) | |||
| hsCRP*Sex | .90 (.31-2.64) | hsCRP*Sex | 1.24 (.27-5.73) | hsCRP*Sex | 2.40 (.37-15.71) | |||
| (2) Age 60-70.5b | n = 1176 | 20 | (5) Age 60-70.5 | n = 1176 | 6 | (8) Age 60-70.5 | n = 1176 | 14 |
| Model 1 | 1.85 (.89-3.85) | Model 1 | 4.20 (1.05-16.77) | Model 1 | 1.31 (.50-3.39) | |||
| Model 2 | 1.83 (.85-3.93) | Model 2 | 5.77 (1.32-25.35) | Model 2 | 1.12 (.41-3.02) | |||
| Model 3 | 2.34 (1.02-5.35) | Model 3 | 11.32 (2.01-63.67) | Model 3 | 1.29 (.44-3.80) | |||
| Model 4 | 2.37 (1.01-5.58) | Model 4 | 14.20 (1.80- 112.22) | Model 4 | 1.29 (.42-3.96) | |||
| hsCRP*Age | 1.10 (.82-1.46) | hsCRP*Age | 1.07 (.59-1.95) | hsCRP*Age | 1.58 (1.03-2.42) | |||
| hsCRP*Sex | 2.40 (.37-15.71) | hsCRP*Sex | 9.02 (.15-552.04) | hsCRP*Sex | 1.67 (.48-5.78) | |||
| (3) Age 70.6-94b | n = 974 | 32 | (6) Age 70.6-94 | n = 974 | 17 | (9) Age 70.6-94 | n = 974 | 15 |
| Model 1 | .36 (.18-.74) | Model 1 | .35 (.13-.93) | Model 1 | .48 (.16-1.46) | |||
| Model 2 | .36 (.18-.73) | Model 2 | .33 (.13-.89) | Model 2 | .50 (.16-1.5) | |||
| Model 3 | .35 (.17-.74) | Model 3 | .31 (.11-.84) | Model 3 | .53 (.17-1.68) | |||
| Model 4 | .39 (.19-.84) | Model 4 | .34 (.12-.96) | Model 4 | .54 (.16-1.81) | |||
| hsCRP*Age | .93 (.77-1.13) | hsCRP*Age | .77 (.58-1.03) | hsCRP*Age | 1.07 (.82-1.39) | |||
| hsCRP*Sex | .65 (.14-2.99) | hsCRP*Sex | .64 (.08-4.97) | hsCRP*Sex | 1.54 (.08-30.13) | |||
Results of the total sample (age ≥ 60) are shown in the upper left section (1), in age group 60-70.5 in middle left section (2) and in age group >70.6 in lower left section (3). Section 4-9 show analyses according to time from baseline (HUNT 2) to debut of AD, in different age groups
aNumber of dementia cases
bAge when examined in HUNT 2
cModel 1: log transformed high specificity C-reactive protein (hsCRP)
dModel 2: hsCRP, age, sex, education
eModel 3: hsCRP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, creatinine, body mass index, pulse
fModel 4: SBP, age, sex, education, cholesterol, triglycerides, non-fasting blood glucose, glomerular filtration rate, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status