Table 4.

Number of hospitalisations with an associated diagnosis of erythema multiforme (EM) and Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) per million sold packages of drug classes involved in adverse reactions; Mainland Portugal, 2010–2014 (n = 215 hospitalisations)

Drug class	EM (N = 90)	SJS/TEN (N = 125)
Antibiotics (NPS = 37,311,945)	0.75	0.88
Antiviral drugs (NPS = 686,221)	1.46	8.74
Hormones and synthetic substitutes (NPS = 69,570,259)	0.08	0.10
Antineoplastic and immunosuppressive drugs (NPS = 1,787,045)	3.92	5.60
Agents primarily affecting blood constituents (NPS = 37,608,542)	–	0.11
Analgesics, antipyretics, and antirheumatics (NPS = 71,419,516)	0.12	0.10
Anticonvulsants (NPS = 16,305,856)	0.43	1.17
Psychotropic agents (NPS = 100,008,577)	0.01	0.03
Agents primarily affecting the cardiovascular system (NPS = 198,300,264)	0.01	0.01
Uric acid metabolism drugs (NPS = 5,007,028)	2.40	4.99

NPS number of drug packages sold