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. 2018 Jan 22;9:13. doi: 10.1186/s13287-017-0766-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — IL-6 and IL-6R stimulate each other’s expression in BM-MSCs. a IL-6 secretion in BM-MSCs was increased by exogenous sIL-6R but decreased by IL-6R-neutralizing antibody during osteogenic differentiation. b Western blotting results showed that mIL-6R expression in BM-MSCs was induced by exogenous IL-6 but reduced by IL-6-neutralizing antibody. Data are presented as the means ± SD of 15 samples per group. *Indicates P < 0.05 compared to the induction group. IL-6 interleukin 6, IL-6R interleukin 6 receptor