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Scheme of the design of the anti-EGFR Goldbody. (A) Structure of the antibody 7D12 (cyan, with CDR3 shown in magenta) in complex with domain III of sEGFR (green) (PDB ID code 4KRL). (B) Sequences of CDR3 of 7D12 and synthesized peptides. (C) Model of the anti-EGFR Goldbody (with the grafted peptide loop shown in magenta) in complex with sEGFR (domain III shown in green, with domains I, II, and IV in gray).
