Table 7.
Association analysis of SNPs in the IL1F7 gene with different genders of patients with RA*
| Genotypes | n† | 1, n (%)‡ | 2, n (%)‡ | 11, n (%) | 12, n (%) | 22, n (%) | ||
|---|---|---|---|---|---|---|---|---|
| rs2723186 | ||||||||
| Female | ||||||||
| CON | 554 | 961 (86.7) | 147 (13.3) | 419 (75.6) | 123 (22.2) | 12 (2.2) | ||
| RA | 469 | 795 (84.7) | 143 (15.2) | 332 (70.8) | 131 (27.9) | 6 (1.3) | ||
| Male | ||||||||
| CON | 143 | 249 (87.1) | 37 (12.9) | 111 (77.6) | 27 (18.9) | 5 (3.4) | ||
| RA | 106 | 183 (86.3) | 29 (13.7) | 81 (76.4) | 21 (19.8) | 4 (3.8) | ||
| rs4241122 | ||||||||
| Female | ||||||||
| CON | 523 | 835 (79.8) | 211 (20.2) | 337 (64.4) | 161 (30.8) | 25 (4.8) | ||
| RA | 468 | 731 (78.1) | 205 (21.9) | 290 (62.0) | 151 (32.3) | 27 (5.8) | ||
| Male | ||||||||
| CON | 140 | 226 (80.7) | 54 (19.3) | 93 (66.4) | 40 (28.6) | 7 (5.0) | ||
| RA | 106 | 168 (79.2) | 44 (20.8) | 72 (67.9) | 24 (22.6) | 10 (9.5) | ||
| rs4392270 | ||||||||
| Female | ||||||||
| CON | 538 | 914 (84.9) | 147 (13.7) | 389 (72.3) | 136 (25.3) | 13 (2.4) | ||
| RA | 469 | 793 (84.5) | 145 (15.5) | 330 (70.4) | 133 (28.4) | 6 (1.2) | ||
| Male | ||||||||
| CON | 139 | 248 (89.2) | 30 (10.8) | 110 (79.1) | 28 (20.1) | 1 (0.7) | ||
| RA | 106 | 182 (85.8) | 30 (14.2) | 80 (75.5) | 22 (20.8) | 4 (3.7) | ||
| Genotypes | 2 versus 1 | Recessive model (11 + 21 versus 22) | Dominant model (11 versus 21 + 22) | |||||
| χ2 | P§ | B | P§ | OR (95% CI) | B | P§ | OR (95% CI) | |
| rs2723186 | ||||||||
| Female | ||||||||
| CON | ||||||||
| RA | 1.504 | 0.220 | −0.526 | 0.297 | 0.59 (0.22−1.59) | −0.255 | 0.075 | 1.29 (0.98−1.71) |
| Male | ||||||||
| CON | ||||||||
| RA | 0.058 | 0.809 | 0.007 | 0.991 | 1.01 (0.26−3.87) | 0.045 | 0.884 | 1.05 (0.57−1.91) |
| rs4241122 | ||||||||
| Female | ||||||||
| CON | ||||||||
| RA | 0.891 | 0.345 | 0.221 | 0.439 | 1.25 (0.71−2.18) | 0.117 | 0.379 | 1.12 (0.87−1.46) |
| Male | ||||||||
| CON | ||||||||
| RA | 0.163 | 0.686 | 0.510 | 0.330 | 1.67 (0.60−4.66) | −0.135 | 0.630 | 0.87 (0.51−1.51) |
| rs4392270 | ||||||||
| Female | ||||||||
| CON | ||||||||
| RA | 1.026 | 0.311 | −0.670 | 0.180 | 0.51 (0.19−1.36) | 0.108 | 0.442 | 1.11 (0.85−1.47) |
| Male | ||||||||
| CON | ||||||||
| RA | 1.263 | 0.261 | 1.609 | 0.154 | 5.0 (0.55−45.67) | 0.233 | 0.451 | 1.26 (0.69−2.31) |
*Association analysis is adjusted for age; †Numbers may not add up to the expected total because of genotyping failure; ‡1: Major (common) allele; 2: Minor (rare) allele. 2/1: rs2723186, A/G; rs4241122, G/A; rs4392270, A/G; §For Bonferroni correction, a corrected P<0.017 is considered significant. CI: Confidence interval; CON: Healthy controls; OR: Odds ratio; RA: Patients with rheumatoid arthritis; SNPs: Single-nucleotide polymorphisms.