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Opn −/− exhibit increased hepatic hematopoietic growth factors and chemokines. (A) Hepatic hematopoietic growth factors (GCSF and MCSF) and (B) chemokines (CXCL1, MIP1α, RANTES, and IL‐6); (C) MIP2, TNFα, and IL‐1β; (D) and serum VEGF are significantly increased in Opn −/− compared to WT mice. Results are expressed as mean ± SD; n = 6/group; • P < 0.05 and •• P < 0.01 for Opn −/− versus WT mice.
