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. 2017 Nov 12;2(1):21–28. doi: 10.1002/hep4.1125

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© 2017 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Minicores circulate in blood. (A) Purification scheme isolating core and minicores. (B) HCV RNA was enriched in the heparin/ Mn⁺² pellet fraction. Error bars represent standard error of technical triplicates. (C) Minicores were detected by western blot in 4 patients with HCV (lanes P1‐P4) and not in 2 normal controls (lanes N1, N2). Cell culture lysate of infected cells served as a positive control (lane C). (D) Duplicate western blots of sample P4 probed with antibodies directed either to the C‐terminal or N‐terminal portion of the core protein confirmed the identity of minicores. Abbreviation: MW, molecular weight; sup, supernatant; term, terminus.