Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Promising epigenetic inhibitors.
| Drug | Inhibitor Type | Targets | (Refs.) |
|---|---|---|---|
| BIX-01294 | HMT(G9a) | H3K9me2 | (59) |
| UNC0638 | HMT(G9a) | H3K9me2 | (60) |
| GSK126 | HMT(EZH2) | H3K27 | (61) |
| EPZ5676 | HMT(DOT1L) | H3K79 | (62) |
| OG-L002 | HMT(LSD1) | MAO-A and B | (63) |
| ORY-1001 | HMT(LSD1) | LSD1 | (64) |
| ---- | HMT (Jumonji C) | LSD1 | (65) |
HMT, histone methyltransferases; LSD, lysine-specific demethylase; EZH2, enhancer of zeste 2 polycomb repressive complex 2 subunit; DOT1L, DOT1 like histone lysine methyltransferase.
