Table II.

Metabolic pathways containing differentially expressed genes enriched in the 4 stages of clear cell renal cell carcinoma compared with control samples.

Pathway	Control vs. stage I	Control vs. stage II	Control vs. stage III	Control vs. stage IV
Androgen and estrogen synthesis and metabolism	X
Propanoate metabolism	X
Cytochrome metabolism	X
Chondroitin synthesis	X	X
Arachidonic acid metabolism	X		X
Eicosanoid metabolism	X		X
Vitamin A metabolism	X		X
Exchange/demand reaction	X	X	X
Blood group synthesis	X		X	X
D-alanine metabolism	X	X	X	X
Transport, extracellular	X	X	X	X
Glyoxylate and dicarboxylate metabolism	X	X	X	X
Xenobiotics metabolism	X	X	X	X
Vitamin E metabolism	X	X	X	X
Vitamin D metabolism	X	X	X	X
Pyruvate metabolism	X	X	X	X
Glycosphingolipid metabolism	X	X	X	X
Phenylalanine metabolism		X	X
Glycine, serine, alanine and threonine metabolism		X		X
Glycolysis/gluconeogenesis		X	X	X
Reactive oxygen species detoxification			X	X
Valine, leucine and isoleucine metabolism				X

X, denotes that the corresponding pathway is enriched by the corresponding comparison (false discovery rate <0.05); blank cells denote FDR >0.05.