Table VI.
Associations between clinicopathological characteristics and CD73 and PD-L1 expressions on gastrointestinal neuroendocrine neoplasms.
| CD73 expression | PD-L1 expression | ||||||
|---|---|---|---|---|---|---|---|
| Clinicopathological feature | No. | Positive | Negative | P-value | Positive | Negative | P-value |
| Age, years | 0.0038 | 0.3299 | |||||
| <70 | 92 | 18 | 74 | 7 | 85 | ||
| ≥70 | 44 | 19 | 25 | 6 | 38 | ||
| Sex | 0.7855 | 0.0759 | |||||
| Male | 82 | 23 | 59 | 11 | 71 | ||
| Female | 54 | 14 | 40 | 2 | 52 | ||
| Location (Duodenum or not) | <0.0001 | 0.0031 | |||||
| Duodenum | 19 | 13 | 6 | 6 | 13 | ||
| Except duodenum | 117 | 24 | 93 | 7 | 110 | ||
| Location (Colorectum or not) | 0.0074 | 0.0020 | |||||
| Colorectum | 87 | 17 | 70 | 3 | 84 | ||
| Except colorectum | 49 | 20 | 29 | 10 | 39 | ||
| WHO 2010 classification | 0.0015 | 0.0011 | |||||
| NET group (G1, G2) | 120 | 27 | 93 | 7 | 113 | ||
| NEC group (NEC, MANEC) | 16 | 10 | 6 | 6 | 10 | ||
| Invasion | |||||||
| Lymphatic invasion | 0.2435 | 0.3871 | |||||
| + | 17 | 7 | 10 | 3 | 14 | ||
| − | 85 | 23 | 62 | 8 | 77 | ||
| Venous invasion | 0.6448 | 0.1732 | |||||
| + | 34 | 9 | 25 | 6 | 28 | ||
| − | 68 | 21 | 47 | 5 | 64 | ||
| CD73 expression | − | <0.0001 | |||||
| + | − | − | − | 11 | 26 | ||
| − | − | − | − | 2 | 97 | ||
CD, cluster of differentiation; PD-L, programmed death-ligand; NET, neuroendocrine tumor; NEC, neuroendocrine carcinoma; MANEC, mixed adenoendocrine carcinoma.