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. 2017 Nov 20;15(2):1475–1482. doi: 10.3892/ol.2017.7445

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Copyright: © Wan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Role of programmed cell death protein-4 (PDCD4) in microRNA (miR)-150 enhanced the cell apoptosis. (A) Dual-luciferase reporter system. The H293T cells were co-transfected with miR-150 mimics and a luciferase reporter containing a fragment of the PDCD4 3′UTR harboring either the miR-150 binding site (WT) or a mutant (MUT). After transfected with siPDCD4, (B) the expression of PDCD4 mRNA was detected by RT-qPCR, (C) cell apoptosis was detected by the Hoechst 33258 assay, and (D) the expression of PDCD4, caspase-8, p21 were detected by western blotting. **P<0.01.