Fig. 4.

Mosaic expression of Gnas^R201H causes enhanced bone fibrosis but reduced bone maturation. Immunostaining (A–D and A′–D′) and quantification (A″–D″) of marker expression as indicated in TdTomato-labeled mutant [Sox9-CreER; Rosa26TdTomato; Gnas^f(R201H)] in wild-type (Sox9-CreER; Rosa26TdTomato) cells. TM was injected at P5 and the humerus was sectioned at P21 for analysis. *P < 0.05, **P < 0.001; data are presented as mean ± SD. Opn⁺ and Osx⁺ cells refer to Opn⁺; TdTomato⁺ and Osx⁺; TdTomato⁺ double-positive cells.