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. 2017 Dec 26;115(2):373–378. doi: 10.1073/pnas.1717125115

Fig. 4.

Fig. 4.

Integrated phenotypic and molecular architecture of leukemic cells from 61 adult and 69 pediatric T-ALL patients. (Top) Age, gender, and immunophenotype for each sample within each of the three unique gene expression groups: TLX1/3/HOXA (G1), ETP/LYL1/HOXA (G2), and TAL1/LMO1 (G3). The second vertical panel presents aberrant gene overexpression known to be associated with chromosome rearrangements and/or fusion transcripts. White labels on red rectangle are used to indicate cases with chromosomal translocations possibly involving TLX3 [t (1, 5) (p11;q35)] and LMO2 [t (11, 14) (p13;q11)] revealed by karyotype analysis (circles; Dataset S1), with amplification of TAL1, NKX2-1, or LYL1 genes revealed by SNP array (triangles) or with insertion of the enhancer regions of TAL1, LMO1, or LMO2 genes (plus signs), respectively. The third vertical panel (heatmap) shows the abnormal expression pattern of a group of genes potentially involved in early T-cell differentiation and hematopoietic regulation. Gene names with an aberrant expression pattern revealed in this work are in red. In the fourth vertical panel, aberrant transcript and fusion genes are presented. (Bottom) CDKN2A/2B deletions and mutations from C1 to C4 categories.