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FOXP3 structure, variation, and the systematic set of mutants. From the Top: conservation of FOXP3 protein across mammals; protein disorder (from D2P2 browser: d2p2.pro/); posttranslational modifications and proline positions; known protein domains; and missense variants in human FOXP3 found in IPEX patients or in population surveys. The position of alanine-scan mutants is shown in relation to these maps, where the number refers to the position of the first altered amino acid.
