Fig. 6.

Pharmacologic activation of Hedgehog pathway facilitates TRC regeneration. (A) Experimental design to examine the effect of Hh agonist on TRC regeneration. (B and C) Representative H&E-stained fungiform papillae from mice treated with vehicle (B) or SAG21k (C) after a 4-wk recovery period following 4 wk of XL139 treatment. (D) Quantification of TRC regeneration as frequency of fungiform papillae (FP) containing TRCs (Left), and TRC index (Right). Shown as relative frequency normalized to vehicle-treated group. n = 5 and 6 mice in each group. [Scale bars: 10 μm (B and C).]