Figure 2.

Wallerian degeneration is faster in mutant mice after p-ERK induction. A, Electron micrographs of ipsilateral sciatic nerve sections 5 d postinjury. Arrows indicate intact myelin sheaths that are quantified in B. C, Macrophage count in TEM pictures reported as the number of macrophages per square millimeter. D, Western blot analysis of MBP expression in MEK1DD mutants (MEK) compared with controls (Ctr). Calnexin was used as a control. n = 3 mice/group. Scale bar, 10 μm. *p < 0.05, ***p < 0.001, two-tailed unpaired t test. Error bars indicate SEM.