Figure 4.
GABACR-dependent rod bipolar cell sensitization is TTX-sensitive. A, Representative traces from ERG recordings of GABACR knock-out mice and WT mice with or without injections of TTX or TTX and GABA. Conditions of dark or light adaptation and flash intensities are indicated in the panels. B, Rod bipolar cell sensitivity for the animal groups represented in A was normalized to the dark sensitivity of WT mice and plotted as a function of background light. C, Representative traces from ERG recordings of WT mice and GABACR knock-out mice with or without injections of TTX or TTX and GABA. D, Rod bipolar cell sensitivity for the groups represented in C was normalized to the dark sensitivity of WT mice and plotted as a function of background light. Between 3 and 12 eyes were analyzed for each condition; data are presented as mean ± SEM.