Figure 5.

AIS length is negatively correlated with proximity; honoring this constraint gives an apparent dependence on position. A, Experimental data show AIS length negatively correlates with the distance from the soma to the proximal border of the AIS. B, Experimental data show AIS length is not correlated with the distance from the soma to the distal border of the AIS. C1, C2, Lengths of the axon-bearing dendrite and AIS were artificially covaried in the model, keeping their total length constant by keeping the distal border of the AIS fixed (solid arrowhead) and reciprocally modifying AIS length and soma-to-AIS proximal border distance (open arrowhead) in the actual morphology (C1). This covariation reproduces the physiologically observed negative correlation of soma to AIS distance with firing rate (Fig. 3E). Spearman's correlation coefficient (r) is shown in A and B.