Table 2.
Parameter | Not AIS | AIS |
---|---|---|
Vhalf, m | −34.6 mV | −39.6 mV |
Vhalf, h | −56.8 mV | −61.8 mV |
Sm | 6.0 | 10.0 |
gNa | 550 μS/cm2 | 27500 μS/cm2 |
gKV | 665 μS/cm2 | 19950 μS/cm2 |
Note that in addition to increasing gNa, the voltage dependence of the Na+ channel in the AIS had to be shifted in a hyperpolarized direction to guarantee that the action potential originates in the AIS, and that the delayed rectifier conductance in the AIS must also be increased to repolarize the action potential.