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. 2018 Jan 17;38(3):733–744. doi: 10.1523/JNEUROSCI.1432-17.2017

Table 2.

Axon initial segment parameters that differ from the rest of the neuron

Parameter Not AIS AIS
Vhalf, m −34.6 mV −39.6 mV
Vhalf, h −56.8 mV −61.8 mV
Sm 6.0 10.0
gNa 550 μS/cm2 27500 μS/cm2
gKV 665 μS/cm2 19950 μS/cm2

Note that in addition to increasing gNa, the voltage dependence of the Na+ channel in the AIS had to be shifted in a hyperpolarized direction to guarantee that the action potential originates in the AIS, and that the delayed rectifier conductance in the AIS must also be increased to repolarize the action potential.