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. Author manuscript; available in PMC: 2018 Jan 22.
Published in final edited form as: J Alzheimers Dis. 2015;43(1):93–108. doi: 10.3233/JAD-140606

Fig. 4. Profound inflammation in AD.

Fig. 4

RNA from peripheral blood of AD patients (n=9) and healthy controls (n=10) were assayed by genome-wide gene expression microarrays. Significantly altered genes (≥2-fold FDR≤1%) detected by microarrays in AD blood were analyzed for functional association, using IPA. a. Heat maps on immune gene alterations (273 gene) were generated using MeV analysis software: AD1–9: AD patients; C1–10: healthy controls; Red: up-regulated genes in AD; Green: down regulated genes in AD; Color intensity: degrees of changes. b. Functional interactions of significantly altered immune genes associated with AD neuropathology were identified using IPA: solid line: direct relationship; dash line: secondary relationship. *Gene symbols and the direction of gene alteration are shown Supplementary Table S2.