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. 2017 Oct 12;103(1):179–189. doi: 10.3324/haematol.2017.174706

Figure 4.

Figure 4.

Hazard ratios and 95% confidence intervals for (A) Advate versus Factane and (B) Kogenate versus Factane according to several models, two propensity score methods and two sensitivity analyses. Three outcomes are shown: all inhibitors, high-titer inhibitors, and inhibitors subsequently treated with a bypassing agent and/or immune tolerance induction. Except in PS analyses and in the first sensitivity analysis, 131, 137, and 127 PUPs first treated with Factane, Advate and Kogenate, respectively, were considered. In Panel A, 110 PUPs first treated from 2004 with Factane and 137 PUPs first treated with Advate were considered in PS analyses and in the first sensitivity analysis. In Panel B, 92 PUPs first treated until 2012 with Factane and 122 PUPs first treated until 2012 with Kogenate were considered in PS analyses; 99 PUPs first treated until 2013 with Factane and 127 PUPs first treated with Kogenate were considered in the first sensitivity analysis. EDs: Exposure days; HR: hazard ratio; PS: propensity score; PUP: previously untreated patient.