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. Author manuscript; available in PMC: 2018 Feb 28.
Published in final edited form as: Nature. 2017 Aug 30;549(7670):48–53. doi: 10.1038/nature23874

Figure 1. hm-NAS genes in gastrointestinal microbiota.

Figure 1

a, Phylogenetic tree of N-acyl genes from PFAM13444. hm-NAS genes have a circle at the branch tip. Black dots were not synthesized, red dots were synthesized but no molecule was detected and large grey dots mark genes that produced N-acyl amides. Branches are colored by bacterial phylogeny. b, The major heterologously produced metabolite from each N-acyl family (1–6) is shown. c, hm-NAS gene distribution and abundance [Reads per Kilobase of Gene Per Million Reads (RPKM)] based on molecule family (1–6). Body site and molecule designations in a are based on the analysis shown in c and b. Box plots are median from 1st to 3rd quartile. HMP patient samples analyzed include N = 133 tongue, 127 plaque, 148 stool, 122 buccal.