Isolated and LPS stimulated bone marrow cells from CTSD−/− and corresponding wildtype littermate controls. Reduced secretion of cytokines TNF-α, IL6, IL10, IFNγ, and MCP in CTSD−/− mice. *, p < 0.05. Data points show mean ± S.E. of five or more experiments in each group and at each time point. Asterisks indicate differences significant at p < 0.05.