Figure 6.
Model of CaV1.2 channels dynamics in dendrites of cultured hippocampal neurons. Full-length and truncated channels are present in neurons. Activation of NMDA receptors (NMDAR, yellow rectangle) causes the cleavage of the CaV1.2 C terminus (19) (A), which allows the PKA to phosphorylate Ser-1700 (12) (B). Ser-1928 is also a substrate for PKA (B). The majority of channels is clustered in signaling complexes. Outside of clusters, mobile channels are diffusely distributed (5). In young neurons pSer-1700 and pSer-1928 promote the diffusive behavior of extra-clustered channels (C). In mature neurons only pSer-1700 favors the CaV1.2 diffusive state, whereas pSer-1928 stabilizes the channels at the clusters (D).